Is PRGF Gel Safe in Presence of Biofilm? (Photos)

Question

Hi...I have a confirmed biofilm from ha filler in my cheek and significant volume loss from the corticosteroid shots I was given afterward. I've been told PRP and PRF may be too risky, but a cursory reading online makes it look like PRGF may be safe. Is that the case? Any insight would be most appreciated. Thank you.

Anna Chacon, MD, FAAD · Answer

In the presence of a biofilm, particularly one associated with hyaluronic acid fillers, treatment options require careful consideration. Biofilms can complicate the healing process and increase the risk of infection or adverse reactions. Here's an overview of the situation and the potential use of PRGF (Plasma Rich in Growth Factors):

Biofilm Concerns:
Biofilms are structures formed by bacteria that can adhere to surfaces, including those of dermal fillers. They are challenging to treat due to their resistance to antibiotics and immune responses.

PRGF (Plasma Rich in Growth Factors):
Safety: PRGF is derived from your own blood, similar to PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin), but it is specially processed to concentrate growth factors while minimizing inflammatory cells.
Potential Benefits: PRGF may promote healing and tissue regeneration, which could be beneficial in managing volume loss and enhancing skin quality.
Risks: While PRGF might be considered safer due to its autologous nature, the presence of a biofilm could still pose a risk of inflammation or infection.

Considerations:
Given the complexity of your situation with confirmed biofilm, it is crucial to consult with a specialist who has experience in treating complications from dermal fillers.
They may recommend addressing the biofilm (potentially using antibiotics or other medical interventions) before considering any regenerative treatments like PRGF.

Ultimately, a personalized approach is essential, and a thorough evaluation by a qualified professional will help determine the best course of action for your specific circumstances.

Is PRGF Gel Safe in Presence of Biofilm? (Photos)

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