325cc -350cc -375cc: Does 25-50 cc's of silicone make a difference in breast size?

Thank you for the question. Depending on the patient's body type and goals, a 25 cc  difference in breast implants generally do not make a significant difference clinically.  For some patients, a 50 cc difference may make a noticeable difference. In regards to specific size/profile of breast implant, despite good intentions, online consultants will not be able to provide you with  meaningful specific advice.  Ultimately, in person consultation with well experienced board-certified plastic surgeons will be necessary. Careful measurements, dimensional planning, and careful communication will be key.
Generally speaking, the best online advice I can give to ladies who are considering  breast augmentation surgery ( regarding breast implant size/profile selection) is:
1. Concentrate on choosing your plastic surgeon carefully.  Concentrate on appropriate training, certification, and the ability of the plastic surgeon to achieve the results you are looking for. Ask to see lots of examples of his/her work.  
2.  Again, have a full discussion and communication regarding your desired goals with your plastic surgeon. This communication will be critical in determining which operation and/or breast implant size/type/profile will most likely help achieve your goals.
In my practice, the use of photographs of “goal” pictures (and breasts that are too big or too small) is very helpful. I have found that the use of words such as “natural” or "C or D cup" etc means different things to different people and therefore prove unhelpful.
 Also, as you know, cup size varies depending on who makes the bra; therefore, discussing desired cup  size may also be inaccurate.  The use of computer imaging may be very helpful during this communication phase.
3.  Once you feel you have communicated your goals clearly,  allow your plastic surgeon to use his/her years of experience/judgment to choose the breast implant size/profile that will best meet your goals.  Again, in my practice, this decision is usually made during surgery.  The use of temporary intraoperative sizers with the patient in the upright position are very helpful.  I hope this, and the attached link, helps.

25-50 cc are increasingly incremental differences in size. They matter more in a smaller breast and with smaller implants. We have our patients spend a great deal of time "sizing" prior to their procedure in addition to performing "dimensional analysis" of their breasts. This allows us to collaborate with the patient to hopefully provide them with the best result we can.

Differences of 50 mL are very subtle and possibly can only be noticed by trained professional. Significant differences start in my opinion from 75 mL to 100 mL that a patient can notice.