Is it ok to drink water with lemon first thing in the morning while on Accutane?

Of course. You can drink this any time of the day. The important thing is to take your Accutane with FOOD though. This helps it absorb better and means you will get more of the mg of the actual medication into your system."This answer has been solicited without seeing this patient and
cannot be held as true medical advice, but only opinion. Seek in-person
treatment with a trained medical professional for appropriate care."