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Not really. Accutane works with oil glands. Milia are not caused by oil glands. Usually people prone to milia are overly aggressive with their skin - rubbing, scrubbing, touching, and this is why they are prone to milia. The best course for stopping milia is a mild cleanser, keep your hands OFF your skin, and use a Clarisonic twice a day. "This answer has been solicited without seeing this patient and cannot be held as true medical advice, but only opinion. Seek in-person treatment with a trained medical professional for appropriate care."