Dear Doctor, Roche said: "oral absorption of isotretinoin is enhanced when given with a high-fat meal. Both peak plasma concentration (Cmax) and the total exposure (AUC) of isotretinoin were more than doubled following a standardized high-fat meal when compared with Accutane given under fasted conditions". My meal while on Accutane just has normal fat like: pan-fried meat, vegetable, bread (no milk). Does it affect the absorption of Accutane? What's the key? Thank you, Doctor! Bests,