In the past, Botox was used in the forehead and crows' feet near the eyelids. Fillers were used in the smile folds and lips. During the last decade +, there has been great advance in the understanding of the aged face. Fat atrophy is responsible for the lack of support and drooping of the face. Botox is used for wrinkles related to muscle movement and the skin that folds above this motion repeatedly. Once the muscle doesn't move, the skin doesn't act like an accordion and eventually the lines diminish if not disappear. Lower facial lines are treated better wtih fillers because inhibition of muscle movement would cause an inability to correctly smile, speak or eat. Lately we have started to add fillers to the upper face. Temple wasting, lateral eyebrow support to recreate a youthful appearance and help elevate a droopy upper eyelid, and cautious filling superficially of the "eleven" in the glabellar region of the forehead (between the eyebrows) are a few of the upper facial filling areas. Botox has been used to diminish the gummy smile, minimize nasal tip movement with speech in some people who have this trait, lessen a dimpled appearance of the chin, and help elevate the corners of the mouth, and even the jowls by treating the DAO and platysma muscles, respectively. These off-label uses should be done by an experienced physician.