How Much Saline Do You Put into the Botox Bottle

Question

so that if you use a insulin syringe, the recnstiuted Botox is correctly reflected by one unit on the insulin syringe.

David Hansen, MD · Answer

Botox is mixed with 2.5 cc saline per 100 unit bottle usually now but some docs will use 1 cc and some use 3 -4 cc. Whatever the concentration that they mix up, they know the units they are injecting to each area so trust them. Botox can be even further diluted when you are getting it for sweating palms, feet and under arms. Don't try to inject Botox if you are not a doc or RN. There are definite techniques we use for different effects and areas.

Ron Shelton, MD · Answer

Whether the physician dilutes the Botox powder with a diluent of 1, 2, 2.5 or 4 ccs of saline, the important variable which determines your result, is the total number of units given. If doctor B uses a 2cc dilution they will have to give twice the volume of diluted Botox to create the same effect as doctor A who uses a 1 cc dilution. Both doctors will have administered the same number of units! If the dilution is excessive, then the larger volume might make the Botox travel via gravity or spread of fluid to surrounding areas and there might be an affect on muscles that were not targeted.

Ran Y. Rubinstein, MD · Answer

Allergan recommends mixing 2.5 cc of saline per 100 units of Botox.
There is a wide range of what doctors use--anywhere from 1 to 4 cc per 100 units. I think what is more important in achieving the results you desire is

Skill of injector--who is injecting you?
Make sure using real Botox
Make sure it isn't watered down
Make sure fresh Botox

Good luck!

Scott Trimas, MD · Answer

Typically, botox is diluted from 1 to 4cc of saline depending upon the injector and his or her experience. In my opinion, the most important consideration is how many units are you receiving for a particular area. Inadequate units are the most common reason for a less than desired effect while too many units or injection in the wrong place can cause side effects like eyelid or eyebrow drooping.

Otto Joseph Placik, MD · Answer

I would refer to the package insert when it comes to preparing and injecting Botox for administration.
There are many marks on the insulin syringe and if you are referring to the o.1ml mark than diluting it with 1cc of saline.
I hope that you are a medical professional asking this question with the proper credentialing to prepare this.

Steven Wallach, MD · Answer

Every doctor varies his dilution of botox so that it works for them. I prefer to keep it fairly concentrated. This usually means 2 cc's of saline so that I get about 50 units per 1 cc syrringe. Others double that number.

Stella Desyatnikova, MD · Answer

It is really up to your treating physician to decide how they want to prepare the Botox solution. We all use different dilution techniques. The number of units you are getting is the variable that is important, as well as the injection technique. 
If you are an individual trying to prepare your own Botox solution, perhaps you should remember: "Don't try this at home" - you need more than a website tutorial to treat a patient with Botox. This is not something you want to experiment with. It's your face.

Mary P. Lupo, MD · Answer

Doctors use several different dilutions: anywhere from 1cc up to 2.5cc for the face, and often 4-5cc for hyperhidrosis are the usual dilutions. Dilution is for the convenience of the doctor, as is the syringe chosen. It is the units injected that make the difference.
I would assume that you choose an expert injector. You then defer to their experience and technique. I cannot imagine why you would want to know such detailed information, but my gut says you somehow got some Botox online and you want to self-administer. Lot of that going on, to disasterous results. I'd rethink that decision.

John Whitt, MD (retired) · Answer

I use 2.5cc of saline for a vial of Botox. However, this is an individual physician's choice and should matter little, if any. Most plastic surgeons charge by the unit rather than by the volume used.

How Much Saline Do You Put into the Botox Bottle

Answers (9)

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