It would not affect the results. As far as I know there would not be an efficacy issue. However, Accutane may cause an elevation in liver enzymes and the combination with a known hepatic toxic entity could be dangerous. When we do blood work we are monitoring two things: triglycerides and liver enzymes ( some physicians might also monitor CBC's and CPK (for muscle injury in addition). Thus, we do place importance on this. I study, about two years ago, was somewhat reassuring in that it showed hepatic insult from Accutane was a little less common than we thought. Frequently, when bringing up the possibility of placing one of my patients on Accutane, a parent questions me about possible liver damage. I can say, I only had one patient with a significant liver enzyme elevation. However, I it was my feeling that she was an alcoholic. ( After stopping her Accutane, I never saw her again...thus I never had the opportunity to ask...it is just something any physician who has spent time practicing in a city or VA hospital can sense.) Thus, while alcohol should not inhibit the positive effect of Accutane, drinking should be held to an absolute minimum.