Questions always arise as to what is the newest and greatest filler and whether it is possible with these new fillers to erase the lines of time. Evolence is a new porcine or pig-based collagen that has been recently approved and released by the FDA. It has been researched initially in Europe and Israel and is now available throughout the world, including the United States.  

Evolence is derived from a pig or porcine source, which is felt to have very, very low allergic potential. It is new and exciting because it has unique characteristics that separate it from other fillers available on the market. Studies in the United States show that Evolence has comparable longevity to the hyaluronic acid derivatives such as Restylane and Juvederm, lasting six months. However, studies in Europe have suggested that this filler may have longevity of up to 12 months.  The reason this product lasts somewhat longer than the hyaluronic acid derivatives is felt to be secondary to its unique way of linking the strands of the collagen molecule together. It has a very unique patented technology called Glycomatrix™, which is responsible for the unique structural characteristics and longevity noted with this filler.    Evolence also has excellent flow characteristics, which again give it a very smooth and natural appearance. Evolence also is well liked by consumers and physicians because it gives the face excellent structural integrity.

The question comes up as to who is the best candidate to use this unique filler. Anyone with deep folds on the face, along the cheek folds or along the marionette lines or for fine lines on the upper or lower lip or for localized volume replacement on the face, would be appropriate candidates for Evolence.

Evolence safety has been shown to be remarkable in multiple studies and requires no skin testing. A second generation filler called Evolence Breeze is now under investigation, which can be used for shaping and molding the lip naturally. Evolence is truly the re-birth of the collagen molecule.

Article by
New York Dermatologic Surgeon