Depends on the region and the doctor

Unfortunately, many medical insurance compaie are pulling away from covering breast reduction surgery.  More unfortunately, those who still do cover it generally only pay the doctor a tiny fraction of the bill.  It takes 3+ hours in most cases for a well skilled plastic surgeon to do a full breast reduction because of the shaping and sewing needed to give you the best result.  You should save your money and go to the best person because you only want to do this once.  The cost would vary widely depending on your region, whether it was done in a physician's office surgery center or a hospital setting.  Total costs all included would probably range from $10-20,000.