Breast reduction surgery can offer significant relief for women who experience physical discomfort, such as back, neck, or shoulder pain, from excessively large breasts. This procedure can also boost self-esteem and improve overall quality of life. For women who are overweight, it's important to note that breast size is often influenced by body weight, as breasts are composed of both glandular tissue and fat. While the glandular tissue removed during breast reduction typically does not regenerate, any weight gain after surgery can cause the remaining breast tissue to increase in size again, potentially leading to enlargement. Many surgeons recommend achieving a stable weight before undergoing breast reduction to help ensure more predictable and long-lasting results. If weight loss is planned, it may be beneficial to wait until you’ve reached your desired weight to undergo the procedure. This is because the breast size and shape can change with fluctuations in weight. If you are unable to lose weight beforehand, breast reduction can still be a viable option, but maintaining a stable weight post-surgery is important for optimal results. Consulting with an experienced plastic surgeon will help you understand the best timing for the surgery and manage expectations based on your unique situation. Dr. Krishna Vyas, MD, PhD, MHS Harvard, Johns Hopkins, & Mayo Clinic Educated Double Fellowship Trained Aesthetic Plastic Surgeon New York, New York