Arnold R. Oppenheim, MD

     Differin ( Adapalene) is a bit different than its two Retinoid mates Tretinoin ( Retin A, Atralin, Avita, Tretin X,) and Tazarotene ( Tazarac, Avage).  It is a third generation retinoid and its molecular structure differs from the other two. 

    All three of these reinoids activate retinoid receptors (RAR) in the skin, but which ones they activate varies. RAR-gamma and RAR-alpha are found in the epidermis. RAR-Beta is located in the dermis. Tretinoin activates all RAR pathways; Tazarac activates RAR-Beta and RAR-gamma; Differin activates only RAR-gamma. 

    Differin, is not a natural Retinoid like the others, but was designed by some pretty creative scientists at Galderma. This adaptation from the original retinoid molecule gave it  increased specificity to maximize its anti-acne benefits and minimize its irritation. Most of my dermatology colleagues would agree with me that Differin is less irritating than its competitors. It also is more stable in the sun. ( By the way, dermatologists prescribe Retin A and Tazarac to be used at night not only to avoid possible redness from the sun, but also to prevent its breakdown and loss of potency. 

    There have been a satchel full of articles on the anti-aging properties of Tretinoin. While Tazaratene has been less studied in this regard, but the studies have all been positive. Taz does slow down the wrinkling process. However, although studies on Differin for wrinkling may be on-going they have not been published. 

    One could argue, that due to Differin's more gentle nature, it could be used if patients are irritated by Tazarac or Tretinoin ( even its more bland derivative Renova). However, if you are irritated by the other two, I would suggest you buy Retinol OTC. This would be less expensive and probably as effective as Differin.  Roc and Oil of Olay make good Retinol products.