You should be fine as long as your other kidney is working properly. No systemic effects have been reported with deoxycholate, the active ingredient in Kybella, in the amount being given. The FDA recommendation is a maximum dose of 10 ml (5 vials) of Kybella which is a 1% solution of the dexoycholate. You may have heard about a mixture of phosphatidylcholine and deoxycholate ( and other ingredients) given in large amounts and called "lipodissolve". A literature review suggested that 9 of 25 articles reviewed on "lipodissolve" showed some systemic side effects including acute liver dysfunction and acute renal failure. But these were in patients getting a much larger amount of the combined mixture, and other ingredients were also present. The FDA issued a warning about lipodissolve in 2010. But Kybella has passed the FDA's rigorous screening process for being safe and effective.A study 30 volunteers who had 4 sessions of injections of deoxycholate in the abdomen at various concentrations including 2.5 times more concentrated solutions and in larger doses vs a placebo to check the effects on the subcutaneous fat also showed "no systemic effects noted" in a study done in 2007 and reported in a scientific journal. So even in larger doses no systemic issues were found in controlled studies with larger amounts then are given in the submental area. So as long as your physician sticks to the FDA recommendation of a maximum dose of 10 ml (5 vials) of Kybella you should be fine.