The answer is of course, yes, there is a risk of resecting too much breast tissue but good planning and analysis of the existing anatomy should limit this risk. Resecting too much tissue can result in excessively small or mis-shapen breasts but it can also produce healing problems as well as necrosis of skin, fat, or nipple. If one has very large breasts, the more that is removed, the higher the chance that blood supply to critical areas such as the nipple is reduced causing healing problems. These complications can be difficult to correct. That is why it is important to analyze your anatomy and discuss your goals and risks completely with your surgeon.Robin T.W. Yuan, M.D.