The risk of side effects after spider vein treatment is relatively low in the hands of an experienced vein specialist. Always research the physician doing the procedure & make sure that they are appropriately qualified to be doing vein treatments and that they are board certified in treatment of vein diseases. Board Certification in Vascular (blood vessel) conditions is preferred.
Risk including 1) allergic reaction to the medication injected, 2) abnormal skin discoloration known as hyperpigmentation or hemosiderin staining which results from pigment depositing in the skin as a result of red blood cell destruction and skin inflammation, 3) matting, which is the development of a cluster of capillaries or small spider veins around the injected area that often looks like a bruise, 4) development of skin ulcerations or wounds (a rare side effect), thrombophlebitis (inflammation and small clots occurring inside leg veins), or recurrence of the veins with failure of the veins to resolve.
Luckily most patients get good results with sclerotherapy and are very satisfied with the results and rarely get these side effects, with an approximate 10-15% skin side effect rate. Over 90% of patients who develop skin side effects will have resolution of the side effects with time, but it can often take many months for the abnormal skin reactions to resolve completely.
I hope that this information was helpful.