The diagonal lines you’re describing that run from the inner corner of the eye down toward the outer cheek sound very much like what we often call the tear trough / lid-cheek junction or a malar groove. Many people think of them as “wrinkles,” but they are often caused by a combination of under-eye hollowness, skin folding, and the natural attachment of the tissues between the lower eyelid and the cheek. If the line is visible even when your face is relaxed, it is usually not just a surface wrinkle, which is important because creams alone rarely eliminate it completely. The most common causes Volume loss under the eyes (can occur even in younger people) Thin skin that casts a shadow A pronounced tear trough ligament Mild cheek volume loss Early skin laxity that creates a fold along the lid-cheek transition What tends to work best 1. Midface / cheek support In many patients, the most natural improvement comes from adding support to the upper cheek rather than injecting directly into the line itself. Restoring cheek volume can soften the transition between the lower eyelid and the cheek and reduce the appearance of the diagonal groove. 2. Tear trough filler (in carefully selected patients) A small amount of hyaluronic acid filler can improve hollowness when performed by someone with extensive experience in the under-eye area. However, if the groove is caused mainly by a strong ligament or skin laxity, filler may not completely erase it and can sometimes create puffiness if too much is placed. 3. Collagen-stimulating treatments If the skin is thin or crepey, treatments such as: Radiofrequency microneedling Fractional laser resurfacing PRF (platelet-rich fibrin) may help improve skin thickness and texture, although they are usually adjunctive treatments rather than a complete solution for a deep groove. What I would avoid expecting Unfortunately, there is no cream or topical product that can reliably eliminate a true tear trough or malar groove. Eye creams may help with hydration and fine texture, but they generally cannot change the underlying structure that creates the diagonal line. Looking at your description specifically Because you mention that the line runs from the inner corner diagonally across the cheek, I suspect this is more of a structural under-eye hollow / malar groove than a simple wrinkle under the eye. Those tend to respond best to a combination of cheek support and, when appropriate, very conservative under-eye volumization rather than trying to “fill the line” aggressively. The encouraging part is that these lines are extremely common and often improve significantly with the right anatomical approach. The key is determining whether the dominant issue is hollowness, ligament tethering, skin thinning, or early cheek descent, because each of those requires a slightly different treatment strategy for the most natural-looking result.