Alopecia areata is fundamentally an autoimmune condition, meaning the immune system mistakenly targets the hair follicle. While oxidative stress has been discussed in the broader context of autoimmune diseases, there is no solid clinical evidence showing that vitamin E supplementation can prevent alopecia areata or reduce the risk of new episodes. Although vitamin E is a strong antioxidant, it does not directly influence the specific immune pathways responsible for the follicular attack in this condition. Vitamin D is somewhat different. We frequently see low vitamin D levels in patients with autoimmune disorders, including alopecia areata, and vitamin D does play a role in immune regulation and normal hair follicle cycling. For that reason, I do recommend checking vitamin D levels and correcting a deficiency if one is present. That said, supplementation in someone who already has normal levels has not been shown to prevent the development or recurrence of alopecia areata. In clinical practice, correcting documented deficiencies is important for overall health and may support a more balanced immune response, but vitamins alone are not a preventive treatment for alopecia areata. When needed, management should focus on therapies that directly address the autoimmune component of the disease.