If a Vial of Unmixed Botox is Left at Room Temperature (Not Frozen) Can It Still Be Used?

A vial of botox unmixed still in the freeze dried state but left at room temerature, is it still usable?

Doctor Answers 9

BOTOX® Cosmetic could be less effective if not stored properly

Depending on how long the vial was left out, it is likely that the product is still acceptable to use but it could reduce the efficacy of the treatment you are offering to paying clients. Much like expiry date on a product, it is still good, but the active ingredients may become left effective.

Montreal Dermatologic Surgeon
4.7 out of 5 stars 21 reviews

Botox effectiveness

Contact the Allergan company to find out. They  have a most wonderfully supportive and academic science department. How many hours is satisfactory to be left at room temperature before dilution and storage, or restorage after delivery.  The Botox is shipped on dry ice to protect it during transportation. It normally is unpacked and placed in a freezer before mixing with sterlie saline.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 37 reviews

If a Vial of Unmixed Botox is Left at Room Temperature (Not Frozen) Can It Still Be Used?

Botox left are room tempature for a very brief time should be ok, IMHO.  Anytime over an hour has not been tested and verified according to my knowledge but Allergan would be the person to ask.  Call your rep and find out.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Botox Storage

It is against Allergan's recommendations to use Botox that has not been stored at the appropriate temperature.  You run the risk of delivering a treatment that may not be effective.  While it is likely that it would be fine, if a patient that is paying for their product, you want to insure that it is efficacious.

Harold J. Kaplan, MD
Los Angeles Facial Plastic Surgeon
4.3 out of 5 stars 6 reviews

Unmixed Botox left out of refrigerator

 It is possible that the unmixed Botox left out of refrigerator will lose it's effectiveness. If it was out for more than one hour, we will not use it. For best and most accurate answer to you question, call the manufacturer Allergan 

A. H. Nezami, MD
Jacksonville Plastic Surgeon
4.8 out of 5 stars 32 reviews

Botox on the shelf

Leaving Botox at room temperature for prolonged periods is not recommended by Allergan.  I keep it on ice or in a freezer/refrigerator. Check with the company.

Steven Wallach, MD
New York Plastic Surgeon
4.1 out of 5 stars 29 reviews

No one knows the answer to this.

Almost every office follows Allergan storage recommendations.  The product is so expensive, there is no reason to leave this to change.  However, it is clear that this product is actually much tougher that initially described by Allergan.  It is likely that product left out on the counter will be just find, even for multiple days.  Again, no office would be deviating from Allergan recommendations so the incentive to actually put this to the test does not exist.  It is worth noting that Xeomin a competing botulinum toxin product requires no refrigeration.

Kenneth D. Steinsapir, MD
Beverly Hills Oculoplastic Surgeon
4.9 out of 5 stars 26 reviews

Botox Storage

I would recommend contacting Allergan.  If the vial has been left out for under an hour, it would probably be fine.  I'm not sure about longer times.  Allergan would know best!

Sheri G. Feldman, MD
Beverly Hills Dermatologist
5.0 out of 5 stars 1 review

Storing Botox

Allergan recommends that Botox be stored in a refrigerator 2-8 degrees Celsius; it no longer needs to be stored in a freezer, though shipments will arrive on dry ice. I would not recommend using vials left at room temperature though your best bet for information on this would be to contact Allergan directly about their storage and use requirements.

F. Victor Rueckl, MD
Las Vegas Dermatologist
4.6 out of 5 stars 17 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.