This question seems to go to the heart of what we call multimodal or combination treatment. In my opinion, you certainly can use Botox, threading, and fillers in combination but it needs to be done in a way that makes sense and that is planned. For example, when performing threading to the neck it may be a good idea to inject Botox into the neck bands (platysmal bands), then wait about 2 weeks before threading to get a tighter neck. This may work in some patients but not well in others. So it really depends on the individual patient. But in my opinion, people tend to get better results with this kind of combination therapy than with threading, botox, or fillers alone. I would recommend seeing a Board Certified Plastic Surgeon who has experience with minimally invasive procedures such as these as well as with cosmetic surgery to find what on the spectrum is best for you. I hope this helps!