Took Mesobotox on Cheeks for Open Pores. After 2 Weeks I Notice Cant Smile or Laugh from One Side of my Face. Is This Permanent?

The technique of mesobotox involves very tiny doses placed very superficially in the skin.  If it is placed too deeply, it can affect the muscles of the face, which could affect your smile.  This effect should not be permanent but could take a few months to resolve completely.  Sometimes it will improve as soon as a week or so also.  

To treat large pores with Botox it should be injected in very small doses in the intradermal layer.  Injecting in the wrong plane, or in excessively high doses, can lead to unintended muscles being affected.  The change in muscle activity is not permanent, and may last up to 3-4 months but could return to normal sooner. 

Mesobotox is a very dilute Botox injected very superficially to help with pores, acne, or fine lines.  If not done properly, it will affect the deeper muscles in the cheek, which will affect your smile.  Over the next 2-3 months, this should resolve back to normal.  There is nothing which can be done in the meantime.