Are there any drug interactions between hydrocodone and Botox?

Question

I had my first Botox injections yesterday for glabellar lines. I do not have visible bruising or swelling from the Botox, and just mild injection site pain (hardly worth mentioning) for which I applied an ice pack. I do not seem to be having any side effects from the Botox. However, before the Botox I had been taking hydrocodone occasionally at night for a bruised rib and back pain because that pain was sometimes keeping me from sleeping.

J. Jason Wendel, MD, FACS · Answer

Thank you for your question.I know of no interaction between these two medications.

To be sure, call your doctor who injected Botox for you.

I hope this helps.

John Layke, DO, FACS · Answer

Botox is a purified protein that works locally by blocking the receptors that cause muscle contraction.  Hydrocodone is an opiate derivative that works on completely different receptors.  Therefore, there is no interaction or synergy when using both of these.

Donald B. Yoo, MD, FACS · Answer

While aspirin, aspirin-containing products and other medications that have anti-coagulative properties will increase the risk of bruising during administration of Botox, hydrocodone will have no interaction with Botox.  Botox works only locally in the muscle, and will not have any systemic (whole body) effect in cosmetic dosages.

Michael I. Echavez, MD · Answer

There should be no problem having Botox treatments, or any other cosmetic injectable product,  while taking hydrocodone.

Michele S. Green, MD · Answer

I am not aware of any interaction between Botox and Hydrocodone.  I would suggest you check with your treating physician and make them aware of the situation.

Are there any drug interactions between hydrocodone and Botox?

Answers (7)