Can the Nose Gain or Lose Fat Cells?

The nose is primarily made up of cartilage not fat.  This cartilage can swell if there is trauma or some type of medical condition that would cause swelling to the face. The beauty in this is that once you correct the shape of the nose through altering the cartilage, the results should be permanent and last a lifetime.  -Dr. Salzhauer

No, not really.  Only with EXTREME weight loss or gain.  There is essentially little to no fat in the soft tissues of the nose.