To make things simplistic, knowing there are always exceptions, Botox relaxes muscles under lines that are created by muscle movement such as the "11" in the glabellar forehead between the eyebrows, the upper forehead lines and the crows feet lines at the outer eyelid area. Fillers such as Restylane and Juvederm Ultra help raise up creases that are present at rest, such as the tear troughs, smile folds, marinonette lines and the horizontal labiomental crease between the lip and chin. Volumizers which tend to be thicker fillers such as Perlane, Juvederm UltraPlus and Radiesse and collagen stimulants such as Sculptra are used to plump up depressed cheeks, temples and prejowl sulci (the depression between the jowl and chin along the forward jaw).