No, sun exposure will not affect the effects after receiving Botox. I advocate daily use of a broad-spectrum sunscreen—particularly after receiving cosmetic wrinkle treatments as the results of these wrinkle treatments won’t last if you continue to get unprotected sun exposure.The reason: Exposure to the sun’s ultraviolet rays (which can even penetrate through car and office windows) breaks down collagen and elastin in the skin, damaging the DNA of skin cells (the genetic coding that determines how your skin ages). This process triggers premature aging of the skin (e.g. fine lines, wrinkles, hyperpigmentation, dryness, and loss of elasticity), as well as skin cancer.