Which type of exosomes are the best?

Question

Currently there are some exosome products in the market, some exosomes came from human stem cell while others are plant-based exosome. I'm wondering if which type of exosomes are the best and the most effective. My problem is dull skin and some ice-pick scars from acne.

Anna Petropoulos, MD, FRCS · Answer

Hello yyskater and thank you for your question! Exosomes are tiny messengers that help skin cells communicate and heal, and they’ve become a popular addition to aesthetic treatments. There are two main types on the market: human stem cell-derived and plant-based. For example, Benev Exosomes, which come from human stem cells, are packed with powerful growth factors and peptides that support collagen production, speed up skin healing, and improve texture—making them a strong choice for issues like dullness and acne scarring. When used after treatments like microneedling or lasers, they can really boost your results and help with skin remodeling.

On the other hand, plant-based exosomes like EXO/E offer a gentler, more natural option. They still deliver hydration, antioxidants, and calming effects, and are great for sensitive skin or for maintaining healthy glow between procedures. While they’re not quite as intensive as Benev when it comes to scar repair, they’re still a solid choice if you prefer a plant-derived approach. Ultimately, if you’re targeting ice-pick scars and want more noticeable skin renewal, Benev is likely to give you better results.

I hope this helped!
Genie Alexander, RN BSN for Anna Petropoulos, MD FRCS 
Center for Classic Beauty
Boston & Danvers, MA

Krishna Vyas, MD, PhD, MHS · Answer

Exosome therapy, or the use of extracellular vesicles, is an emerging and promising technology in regenerative medicine, particularly for skin and soft tissue repair. These nano-sized vesicles carry bioactive molecules that play crucial roles in cellular communication, potentially aiding in tissue regeneration. Preclinical studies, primarily involving animal models, have shown exosomes to be effective in promoting skin healing and restoration, and they hold potential for a variety of applications in plastic and reconstructive surgery. Exosome therapy offers the advantage of being cell-free and ready-to-use, which simplifies its adoption compared to traditional regenerative cell-based therapies. However, no exosome products have been approved by the US FDA yet, and more research is needed to establish clear guidelines for their use. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. 
In the field of regenerative aesthetics, exosomes are gaining attention for their potential in skin rejuvenation and hair restoration. As a minimally invasive option, exosomes offer a promising way to address the underlying causes of skin aging and promote tissue health. While the technology is still in its early stages, initial studies suggest that exosomes can improve skin rejuvenation by enhancing cellular communication and restoring tissue balance. Challenges remain in terms of exosome purification, storage, and reproducibility, and while current research shows safety in humans, there is a lack of consensus on long-term efficacy. Further clinical studies are required to determine which patients will benefit most from exosome therapy and to ensure regulatory compliance before widespread use in aesthetic medicine.
Krishna Vyas, MD, PhD, MHSHarvard, Hopkins, & Mayo Clinic Trained Aesthetic Plastic SurgeonNew York, New York

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