Is it safe to use Retin-a .05% at night after cleansing, and then not wash off again until the next night?

Thank you for the question.Retin A does not need to be washed off.Be sure to use a moisturizer with SPF each morning.Hope this helps

The retinoid cream doesn't offer any added benefit wearing it for 24 hours (vs a few hours overnight), but it shouldn't hurt you to leave it on if that's what makes your skin feel  best. But if dryness is what's bothering you, washing with a mild, nondedicated cleanser in the morning may offer an opportunity for a soothing moisturizer to penetrate and work a little better (moisturizer always works best right after cleansing, when skin is warm and patted dry). Your SPF product during the daytime is essential - keep up the great work!   

Retin-A (Tretinoin) does not need to be washed off the AM.  Just as you have, all my patients apply at night after cleansing, rub in well, then forget about it.  I do recommend AM cleansing as part of most people's skin care, but not to remove the Retin-A--- it was fully absorbed into the skin within the first 1-2 hours after application.