Absolutely. In fact this is the MOST important factor we consider prior to laser resurfacing. Fractional CO2 can be used on all skin types, however the side effects, even when conservative low density (low percentage) modes are used on darker skin types are higher than in lighter skin types. If you have Caucasian type 1-2 Skin, your results will be better than with darker skin types because we can be slightly more 'aggressive' but sill remain safe. If you have darker skin, I use either 1. Fractional Co2 or 2. Fractional erbium. I do use fully ablative erbium laser in Type 3-4, but not CO2.Bottom line- skin type does matter. All the best Dr Davin S. LimLaser and cosmetic dermatologistBRISBANE, Australia.