Salmon sperm injection usually refers to polynucleotide or PDRN treatments. These can improve skin quality, hydration, elasticity, and fine texture, but they do not work like filler and do not truly lift sagging tissue. For nasolabial folds, the result is usually limited if the fold is deep or caused by cheek descent, volume loss, or facial structure. In that situation, polynucleotides may make the skin look healthier, but they will not significantly fill or erase the fold. If the nasolabial fold is mild and mostly related to thin or tired-looking skin, the treatment may give subtle improvement. But if you are expecting a visible lifting or filling effect, hyaluronic acid filler, fat grafting, midface support, or in some cases a facelift may be more appropriate. It is also important that injections around the face are done by an experienced medical professional. Even “skin booster” type treatments can cause bruising, swelling, unevenness, or vascular complications if injected incorrectly. My advice would be to see it as a skin-quality treatment, not a main treatment for nasolabial folds. It may be useful as an add-on, but for a clear fold, the cause of the fold should be assessed first.