Can I take Accutane while on Spironolactone? 23 year old woman, 100 mg dose of spiro

I want to be done with acne so I want to give accutane a try but I also don't want to explode with acne if I get off of spiro. My questions are: Is it safe to take both simultaneously? Will accutane be as effective if on spiro as well? Should I lower my spiro dose while on Accutane? I'm about 106 pounds, what should my dosage be and for how long should I be on accutane?