Upper lip veritcal creases are caused by multiple factors, different for every patient. Smoking, chronic sundamage, dentition and age contribute to the lines. Some lines have been present for so many decades that elimination of the muscle activity below the skin, which had caused the skin to "accordion" and create these lines, won't make the lines go away. Often these stubborn lines can benefit by using Botox pre resurfacing as an off-label indication to minimze the active pursing of the lip muscles so there is less creasing of the skin during the healing of the new skin. The optimal resurfacing may be dermabrasion (sanding), Plasma Portrait resurfacing, Carbon dioxide laser ablative or non-ablative (Fraxel Repair), deep chemical peel, or a series of non-ablative Fraxel Restore lasers (erbium). Fillers also have been used. Some of my patients having Botox as a prelude to fillers or resurfacing did so well that they didn't need the secondary procedures. The skin is not fragile in this location and Botox can work well. It is as said previously, is an off-label indication. There is a risk of elongating or flattening the upper lip, asymmetry (lack of balance from side to side, e.g. a crooked smile) and difficulty eating and speaking correctly, singing difficulty and even dribbling. Very few units (1 - 2 units the most) per site injected, and maybe 4 - 6 units for the upper lip total would be used. The lower lip can be treated similarly. You need to see an experienced physician for this treatment.