Is It Safe to Have Botox on Anti Depressants?

Doctor Answers 18

Botox and depression

Botulinum toxin has actually been shown to improve depression! 

Botulinum toxin was first isolated in the 20s, was first used therapeutically in 1968, and became approved in 1989 for eye issues. It has been used heavily for cosmetic use since 2002, and it was the first aesthetic drug ever approved.  All that is to has a lot of safety data behind it. Recent evidence (coming out this week) proves that botulinum toxin does NOT enter your brain as it's distant cousin tetanus toxin does, which is where that theory came from. 

Botox, Dysport and Xeomin are the 3 botulinum toxins approved for cosmetic use in the US. They all work in the same way, at the presynaptic terminal blocking the release of acetylcholine - making the nerve temporarily unable to communicate with the muscle. It is broken down as a protein in our body with liver metabolism. Effects are temporary, and repeated use serves to take tension off of your skin, relaxing lines and wrinkles.

To ensure you are receiving the highest level of care, seek out a modernly trained, new-school dermatologic surgeon, oculoplastic surgeon, facial plastic surgeon or plastic surgeon who is board certified and fellowship trained in one of these "core four" cosmetic specialties. Membership in organizations like the American Academy of Facial Plastic and Reconstructive Surgery help to identify a highly trained surgeon.

Cameron Chesnut

#realself500 Physician

Spokane Dermatologic Surgeon
4.9 out of 5 stars 105 reviews

Botox is safe with antidepressants but be aware of other issues.


There is no medical safety issue with Botox in someone taking antidepressants, but just be aware of other issues like whether you are emotionally prepared to try Botox, or if you have unrealistic expectations of what can be done with it. I encourage you to try it out. Interestingly, there have even been reports of a few patients saying they feel happier after Botox treatments--this effect is still being studied but is potentially promising.

Jessica J. Krant, MD, MPH
New York Dermatologic Surgeon
4.7 out of 5 stars 41 reviews

Botox may be injected in patients who take antidepressants

There should not be a contraindication against taking antidepressants when having Botox injected.  This class of medication is not on the list of those that should be avoided during Botox treatment.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 38 reviews

Botox and Antidepressants

In my experience I've not seen problems with the injections which have a localized effect on the muscles and not a systemic effect .

Deason Dunagan, MD
Huntsville Plastic Surgeon
4.9 out of 5 stars 12 reviews

Botox and Anti-Depressants - Los Angeles

Hello and thank you for the question.

There is no contraindication to undergo Botox Cosmetic Treatment if you are currently on antidepressants. Consult with you physician prior to treatment to make sure there are no underlying contraindications.

Kindest Regards, 

Glenn Vallecillos, M.D. F.A.C.S. 

Glenn Vallecillos, MD, FACS
Beverly Hills Plastic Surgeon
4.9 out of 5 stars 31 reviews

Botox safe on antidepressants

Yes, there are no complications for Botox administered concurrently with antidepressants. However, any history of neurological diseases must be made known to your physician prior to treatment.

Peter L. Kopelson, MD
Beverly Hills Dermatologic Surgeon
5.0 out of 5 stars 1 review

Yes, you can have Botox while taking Antidepressants

Yes, Botox acts only on the muscles into which it is injected. Antidepressants are systemic drugs taken internally.

Robert E. Zaworski, MD
Atlanta Plastic Surgeon
4.8 out of 5 stars 62 reviews

Botox can be used when on anti-depressants

There is certainly no contra-indication to having Botox injected while one is taking anti-depressants. That said, you should always share with your doctor any and all medications you are taking (including vitamins and supplements and non-Western medications, such as Chinese medicine) during your first visit. On follow-up visits, you should let your physician know about any changes in your treatment regimen. This will help ensure higher quality care. Good luck! 

Dr. Chow in Arcadia, CA

Jen Yuan Chow, MD
Pasadena Facial Plastic Surgeon
5.0 out of 5 stars 1 review

Botox and Anti-Depressants

There is no chemical or physical reason to avoid Botox when taking anti-depressants. Ask the physician managing your depression if Botox will be psychologically beneficial.

Richard W. Fleming, MD
Beverly Hills Facial Plastic Surgeon
4.9 out of 5 stars 39 reviews

Botox, Wrinkle Treatment, Beverly Hills Botox, Los Angeles Botox, Nasal Surgery, Beverly Hills Rhinoplasty

It should be safe to have Botox injections while on anti-depressants but you should discuss this with the physician that's treating you with this medication to be certain.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 25 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.