Does Restylane Increase Collagen Production?

Merely the process of injecting a needle without a filler will stimulate collagen growth, in fact there is a technique of making multiple punctures for skin rejuvenation based entirely on that. Some fillers are intended to be active stimulators of collagen growth, which would prolong the effect. The question then is how meaningful it is in terms of the clinical result. There are many advantages to HA fillers such as Restylane, but if collagen growth is the real goal there may be better ways to do it.

After multiple treatments, the placement itself of Restylane, not the product, may increase the body's production of collagen at the site of injecitons as a response to the healing of the needle insertions.

Thank you for your question. There is evidence that dermal filler injection, such as Restylane or Juvederm, does stimulate the body’s own production of collagen. However, this due to the stretching of the skin cells from the product. I hope this helps. Best of Luck!

Thank you for your question. There is evidence that dermal filler injection, such as Restylane or Juvederm, does stimulate the body’s own production of collagen. However, this due to the stretching of the skin cells from the product. I hope this helps. Best of Luck

All fillers stimulate some collagen production, but the majority of the action of Restylane is related to the actual material and once the material absorbs, the results will go away. However, some collagen is produced just as a reaction to the material or from the needle passing through the area.

There is some evidence that injection of dermal fillers, such as Restylane or Juvederm, does in fact stimulate the body's own production of collagen.  This is not so much because of the product itself, but rather because of stretching of skin cells from the product.

The repeated placement of Hyaluronic Acid fillers (Restylane, Juvederm, Perlane etc) has been associated with local production of collagen which stretches the duration of successive filler placements. In other words, the more times you had a filler, the longer it will last due to local filling of the area with collagen.

It is doubtful that restylane causes significant collagen formation after injection that would eliminate the need for further procedures.

Restylane has not shown to produce collagen in studies. But in my experience, I have seen persistent correction of people for longer than what is advertised.  The thought of what process is going on is that there seems to be scar tissue that is forming around the restylane that prevents is degradation.  This is not an uncommon thing that I have noticed in my practice.  I would say that I have seen this in about 5 % of my patient population where they get much longer acting results from restylane injections.  With the manipulation of the needle and the subsequent bruising, I believe that some collagen production is possible but not consistent in my experience.

Studies by dermatologist John Voorhies (Michigan) have proven that the stretch of dermal fibroblasts by hyaluronic acid fillers like RESTYLANE, stimulate new collagen to be produced. This substantiates the clinical benefit we see from regular filler injections.