Restylane Side Effects

I am planning on having Restylane done on the lines that lead from nose to jawline. Has anyone had any bad side effects from Restylane or from the anesthetic? What should I expect?

Doctor Answers 48

Restylane potential side effects

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Restylane is a very well tolerated filler if applied correctly.  There may be minor bruising and swelling which may last 1-4 days after the injection and which are typically covered by makeup in the relatively unlikely instance they are noticeable.  Nodules and skin color changes are some of the more serious side effects but in the hands of an experienced practitioner, these issues are highly unlikely.  Of course over- or undercorrection can result in unwanted appearance.  Other side effects depend on the area applied, and special considerations need to be made for blood vessels, skin thickness, and lymphatics in the area.  Restylane around the eyes has a higher chance of untoward effects and must be applied with great care.  A thorough evaluation by an experienced practitioner is necessary to identify the best location for placement, the technique to place it, and the potential pitfalls of placement.

Baltimore Facial Plastic Surgeon
4.9 out of 5 stars 62 reviews

Potential risks associated with Restylane

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Risks can occur regardless of surgeon or technique. These include but are not limited to: infection, hematoma, discomfort, asymmetry, undesirable effect on an associated muscle such as drooping of an eyelid, adverse medication reaction, allergic reaction, need for additional "touch up" injections, palpability, visibility, distortion with muscular contraction, need for secondary revisions, and inability to guarantee a specific cosmetic result.

Otto Joseph Placik, MD
Chicago Plastic Surgeon
4.9 out of 5 stars 86 reviews

See an experienced injector

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As long as you are going to an experienced injector, there shouldn’t be any bad side effect, however, a rare complication can occur despite the experience of the physician. Bruising, redness and swelling occur commonly but, they are self limiting. The rare complication is plugging up a blood vessel that can “choke” off the blood supply to the overlying skin which create a bad scab and then a discolored permanent scar. Hyaluronidase can be used immediately if this is noted and the filler gets dissolved and the complication can lessen.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

As long as you go to a good and experienced injector, you should be fine

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Restylane, like any other treatment, is only as good as the person who is injecting it. If you go to someone who is a new injector, prepare to have problems. On the other hand, if you go to an experience injector, preferably a board certified dermatologist or cosmetic surgeon (not a nurse or physician assistant/nurse practitioner), you should be fine. Good luck!

Joel Schlessinger, MD
Omaha Dermatologic Surgeon
4.9 out of 5 stars 50 reviews

Restylane is a great treatment!

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Dear Mare

Restylane has proven to be a fantastic treatment for the nasolabial folds. You should go to an experiences injector. The core specialties that do this service are: Cosmetic dermatology, ocuoplastics, facial plastics, and general plastic surgery. Beyond that, the right doctor irrespective of which of these specialities they are trained in makes a big difference. However, treatment of nasolabial folds is such a standard treatment that you are likely to have a great treatment result. I would recommend that you look at to find a highly qualified injector in your area. This is not a service that should be done by a nurse or an aesthetician.

Kenneth D. Steinsapir, MD
Beverly Hills Oculoplastic Surgeon
4.9 out of 5 stars 26 reviews

Complications from Restylane

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If you are in good health, it is very unlikely for you to get any side effects from Restylane.

Restylane is Hyaluronic Acid which is abundantly present in your skin.

Rare complications may occur, mainly bruising and lumpiness.

Bruising  disappears in 4-7 days (or longer if you take Aspirin, Vitamin E, Garlic, Gingko or Ginseng). Lumpiness can be corrected at the time of the injection by massaging.

Make sure you tell your doctor if you have had a reaction to xylocaine in the past.

Make sure that the injections are being performed by a Board Certified Dermatologist or Plastic Sur geon

Eugene Mandrea, MD
Chicago Dermatologist
4.6 out of 5 stars 5 reviews

Bad Side Effects from Restylane

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Bruising which can last for up to 2 weeks.

Superficial Placement which can look like a blue colored line.

Herpes Simplex flare up causing porlonged pain or sores

Extreme pain if not done with good anesthesia especially in the upper lip.

However, overall it is a very safe and effective and gratifying procedure.


Tanveer Janjua, MD
Bedminster Facial Plastic Surgeon
5.0 out of 5 stars 126 reviews

Restylane risks

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 The main risks are bruising which get better, and contour irregularities which often can be massaged out or additional filler can be added. I have not heard of any allergic reactions to the product although I imagine it can happen but it is very rare.

Steven Wallach, MD
New York Plastic Surgeon
4.2 out of 5 stars 30 reviews

Restylane Side Effects

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Restylane is a safe product and is associated with high patient satisfaction. Although rare, side effects occasionally occur following this type of injection and most often include swelling and bruising. If you’re concerned about the results from Restylane treatments, it’s important to discuss this issue with your doctor, who can address those concerns.

Steven Gabel, MD, FACS
Portland Hair Restoration Surgeon
5.0 out of 5 stars 17 reviews

Side effects from Restylane

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It is very rare to have any serious side effects from Restylane. It is an extremely safe product. That being said, many providers are ordering the product from outside of the United States, which is a growing problem, as the authenticity of the product cannot be verified.

Common side effects;

  • mild to moderate brusing
  • mild swelling

Uncommon side effects:

  • allergic reaction
  • redness at the treated sites

Unwanted results due to injection technique:

  • bumps under the skin due to uneven injection
  • Tyndall effect (bluish color of the skin due to superficial placement of the product)

Robert S. Bader, MD, FAAD
Boca Raton Dermatologic Surgeon
5.0 out of 5 stars 3 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.