Currently, Renuva is cost prohibitive for large volume treatment for most, although it has been used successfully to give more definition to targeted body areas. Renuva is mostly used to replenish age-related small volume loss in the face or hands, and for smoothing and correcting indentations and irregularities in other areas of the body. Renuva is also ideal for helping to contour body areas that can't be achieved through exercise. The makers of Renuva are working on creating a new groundbreaking treatment for larger volume replacement, and we can’t wait. We expect to be able to treat areas in need of large volume, like the buttocks, by March, 2021! To answer your other questions – when injected, Renuva creates a scaffold like framework, known as a matrix, housed with growth factors that the body utilizes to build fat cells. The Renuva matrix dissolves within 3 months after the treatment, leaving your only your body's own fat behind – which creates beautiful, natural-looking results. The fat in the treated area will last as long as your fat cells normally live. This varies from person to person, but several published studies report that fat cells can live 10 years, and more. And yes, Renuva is incredibly safe! Renuva is regulated by the FDA, has passed rigorous safety testing, and a literature review has recently been published in the Journal of Cosmetic Dermatology.