Aczone 7.5% and Retin-A 0.025%: can I apply aczone every 3rd night?

Dryness and irritation are extremely common side effects when you first start a topical retinoid, such as Retin-A. However, dryness and irritation are uncommon with Aczone gel. For best results, I would recommend applying Aczone 7.5% gel once a day. You can apply it every morning, and continue your Retin-A cream every 3rd night. Once you feel your skin has adjusted to the Retin-A cream, I would increase your usage to every other night, and eventually work up to using it nightly.