Do growth factors induced by laser resurfacing treatments (VEGF, cytokines) stay localized in the skin?

Laser resurfacing treatments are known to stimulate the production of various growth factors, including vascular endothelial growth factor (VEGF) and cytokines, which play a role in the skin's healing and rejuvenation processes. These growth factors are primarily involved in local tissue repair and regeneration.

**Localization vs. Systemic Circulation:**
- **Localized Effects:** Generally, the primary effects of laser resurfacing, including the induction of growth factors, are localized to the treatment area. The immediate response involves inflammation, tissue remodeling, and collagen production at the site of the laser application.
- **Systemic Circulation:** While the majority of the growth factors and cytokines act locally, there is a possibility that some of these molecules could enter the systemic circulation. However, the extent and significance of this systemic spread are not fully understood and are likely minimal in most cases.

**Cancer Concerns:**
- **Melanoma History:** Given your history of melanoma, it is understandable to be cautious about any treatment that might theoretically influence cancer cell behavior. While there is no strong evidence to suggest that laser resurfacing significantly increases systemic levels of growth factors to the extent that it would promote cancer recurrence, the theoretical risk cannot be entirely dismissed.

**Recommendations:**
1. **Consultation with Oncologist:** Before undergoing laser resurfacing, it is crucial to discuss your concerns with your oncologist. They can provide personalized advice based on your medical history and current health status.
2. **Dermatologist Input:** A dermatologist who is aware of your cancer history can also help tailor the treatment plan to minimize any potential risks.
3. **Alternative Treatments:** Depending on the advice from your healthcare providers, you may consider alternative skin rejuvenation treatments that may carry less risk in the context of your medical history.

While the growth factors induced by laser resurfacing are predominantly localized to the skin, there is a theoretical risk of minimal systemic circulation. Given your history of melanoma, it is essential to proceed with caution and seek guidance from your oncologist and dermatologist to make an informed decision.