After application of Minoxidil topical solution usp 5%, I have dandruff-like flakes on my scalp. What can I do?

Minoxidil 5% liquid can be quite drying to the scalp mainly due to its propylene glycol component. Irritation and dryness from propylene glycol can lead to flaking. If the flaking is a problem, minoxidil/Rogaine Foam proves to be less drying and irritating to the scalp.  If it persists, your doctor can also prescribe medication for the dandruff.

Minoxidil, which is used to treat thinning hair, can cause dandruff-like flaking as a side effect. The alcohol in minoxidil can dry out your scalp, and after a few months of treatment, dandruff may set in. In most cases, you can solve the problem by switching to another medication or by using a dandruff shampoo accompanied by a conditioner. If your condition does not improve, consult a specialist for an detailed examination. 

Minoxidil does cause dryness to the scalp which results in dandruff. Use some coconut oil at night once a week and switch to a anti dandruff shampoo like Selsun Blue or Head and shoulders and make sure you use conditioner. Hope that helps!

Minoxidil does dry the skin. The foam less so than the dropper version. It contains less alcohol. Also a good zinc shampoo like Head and Shoulders or Selsun Blue work well for the flakes.

Minoxidil can dry the skin. Use a good anti-dandruff shampoo like head and shoulders and a good conditioner to moisten the scalp