One of the big advantages to CEREC crowns is that they can be milled, fitted, and cemented all at the same appointment while you are already numb. In some cases though, a dentist may want you to come back after the preparation appointment. If that is the case and you had to wear a temporary, then you would more than likely want to have some local anesthetic for the delivery/cementation of the crown. The tooth preparation needs to be cleaned very well and in most cases bonding agents placed on it before the crown is cemented. This can be uncomfortable if the tooth is not already anesthetized.
After a crown is delivered most patients do not need pain medication, but ocasionally it can be helpful if you have very sensitive teeth. I would recommend a tylenol 500mg and ibuprofen 400mg together every 6 hours for the first 24 hours.
All the Best!