That is a skin roll. In those who've not had a surgical procedure like liposuction, it represents an attenuation of the fascial ligaments that hold our skin to the deeper muscular fascia, leading to rolling of the skin. This is common in the upper thigh/buttock area. Qwo is collagenase, which is an enzymatic protein designed to break down tight fascial ligaments (collagen) that are believed to cause cellulite dimples; if anything, I would imagine that Qwo could make things worse. Unfortunately, any filler will not improve that issue unless enough of it was use to inflate the tissue. This would leave you with smoother contour, but also a fullness that you would not appreciate. Having said that, using a very judicious amount of fat graft could improve the contour there.