Is topical spironolactone cream effective for hair loss due to androgenic alopecia? Is it effective for hair regrowth?

We have been treating hair loss patients in Cincinnati for over 18 years and have found this product can be effective when used in conjunction with other treatments such as Capillus272.The Capillus272 typically gets the hair that is falling out turned back into the growth phase and the spironolactone can assist if the patient is having scalp issues.I typically do not advise patients use spironolactone for purposes of trying to grow but when used in conjunction with other modalities can be very effective.

There are no good studies to document effectiveness. Anecdotal results are probaby due to systemic absorption.I assume you have tried Minoxidil 5% once per day. They just released a new Foam product.PRP has been reported to be successful.Viviscal vitamins and microneedle rollers would be another option.Thanks

Although spironolactone could be the treatment of choice for some women with androgenetic alopecia, I am not aware of any scientific study that shows any effects from topical spironolactone. 

Topical spironolactone is not FDA approved for androgenetic alopecia and has not had much study.  Any use of topical spironolactone is off label and should be prescribed only in conjunction with a physician.  Is it effective? Well, few such studies have been done but there may be some minor benefit.  A 1997 study studied 60 women using 1 % topical spironolactone. A minor degree of benefit was seen. There is little doubt that topical spironolactone gets absorbed somewhat into the blood - so if one is going to use it you'll need to know everything about if from A to Z. Side effects from topical spironolactone are potentially similar to oral spirinolactone pills (albeit at a lower incidence).  Men should not use spironolactone due to gynecomastia. Women should be aware of breast tenderness, mood changes, electrolyte imbalance, fatigue, dizziness, swelling, Women of child bearing age should speak to their physician about pregnancy concerns. One must never get pregnant while using spironolactone or the developing fetus could be seriously harmed. Spironolactone is a great drug when prescribed to the appropriate patient. But it needs to be respected. Topical antiandrogens do get absorbed into the blood stream. It would be unwise to think otherwise. REFERENCE Dill-Muller D, Zaun H. Topical treatment of androgenetic alopecia with spironolactone. J Eur Acad Dermatol Venereol. 1997 Sep;9(Suppl 1):31.

The use of topical spironolactone cream varies. Are you male or female? What medications are you taking, and what are your blood test results?  Clearly this is a complex issue that requires a one-on-one with a good specialist