There really is no problem in getting Botox injected during the same treatment session immediately following microdermabrasion.That however begs the separate question of whether microdermabrasion is of any real, significant value in and of itself. The benefits of microdermabrasion, a technnique that at one time was appropriately referred to as epidermabrasion, amount to little more than what may be achieved from a vigorous scrubbing with a Buf Puf, Loofah, or even a washcloth. So, I would not rely upon any more than I would upon using exfoliating soaps to achieve significant facial improvement, other than perhaps a nice sheen to the skin. In fact, overscrubbing and rubbing may even aggravate a number of problems, including underlying acne, rosacea and dry skin to name just a few.Good luck to you