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Is it safe to use tretinoin 0.1% & face wash gel with retinyl palmitate together?

Nicki1994Sep 5, 2022
I found an article “Retinol, at concentrations greater than the physiological limit, induces oxidative stress and apoptosis in human dermal fibroblasts” (https://pubmed.ncbi.nlm.nih.gov/15009115/) and now I’m afraid that my skin fibroblasts may have died after regular use of tretinoin gel 0.1% and face wash gel with retinyl palmitate together. Is it safe to use tretinoin 0.1% and retinyl palmitate together and may it induce oxidative stress and apoptosis in skin fibroblasts?

Answers (1)

From board-certified doctors and trusted medical professionals
Dr. David M. Kowalczyk, MD, MBA, FACS
Board Certified Facial Plastic Surgeon
Answered on Sep 9, 2022
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Jonathan Kaplan, MD, MPH

Use hydroquinone on its own in the AM. Then use both hydroquinone and Retin-A at night - doesn't matter which one goes first. You can mix it if you want. If you experience redness, sensitivity, or irritation, use the Retin-A less often.

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Reuel Aspacio, MD, FAAD - Account Suspended

Hello! Unfortunately it is difficult to evaluate your skin in this forum and from the pictures provided. There are multiple treatment options available that can help with hyperpigmentation such as hydroquinone, compounded medications, and laser treatments. These treatment options might not...

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