Are fillers/Radiesse likely to last longer if you get more of them?

Radiesse is a calcium hydroxylapatite-based dermal filler that not only provides immediate volume but also stimulates collagen production over time. The duration of results can vary based on multiple factors, including the amount used, injection technique, and individual metabolic rate.

Generally, larger or more strategically placed volumes can yield longer-lasting and more noticeable results, especially when there's enough product to support collagen stimulation across a broader area. A single syringe may provide modest results that diminish more quickly, particularly if the area being treated would benefit from greater structural support.

However, more product doesn’t always mean significantly longer duration—it depends on how the filler integrates into the tissue and how your body responds. In many cases, a layered or staged approach over time can produce more sustained and natural outcomes.

It’s also worth noting that lifestyle, age, skin quality, and activity levels can influence how quickly fillers break down. A personalized treatment plan that considers both the amount and timing of injections often yields the best results.

Radiesse is a bio stimulating product, much like Sculptra. So it's best to inject it in increments and keep stimulating collagen production. You may need a few syringes at first to gain volume loss. After that, injecting a syringe of filler one to three times a year depending on your age is the way to go!

The quantity of filler should reflect the volume loss to be corrected. The degradation occurs at the same rate and thus time of correction is relatively equivalent. This does not account for under/over treatment. Also, with radiesse, it can be delivered in a hyperdilute formulation with more frequent injections for the purpose of collagen stimulation.

The dissipation effect of any filler depends on how your body metabolizes it. Should you have one syringe or 10 syringes, will not change how your body metabolizes the total amount of filler, but the number of syringes will change the volume effect and the appearance where it’s being injected. I hope this helps soon. Good luck from Leonard Grossman MD New York City, plastic surgery.