Moxi and Clear + Brilliant Permea are both non-ablative fractional lasers utilizing a 1927 nm thulium wavelength, but they differ in their applications and capabilities. Moxi, developed by Sciton, offers a range of customizable settings, allowing for treatments that vary from superficial to mid-depth. This flexibility makes it suitable for addressing a variety of skin concerns, including melasma, sun damage, pigmentation, and early signs of aging. It can be tailored for both light "prejuvenation" and more intensive corrective procedures. Clear + Brilliant Permea, by Solta Medical, is designed for more superficial treatments, primarily targeting the epidermis. It is less customizable compared to Moxi, with a focus on gentle pigment correction and skin brightening. This makes it ideal for treating mild pigmentation, melasma, and improving skin texture with minimal downtime. Both lasers are effective for early signs of aging and have minimal recovery times, typically involving 1–3 days of redness. However, Moxi may cause slightly more redness or swelling if higher settings are used due to its broader treatment capabilities. In summary, while both lasers share the same wavelength and are non-ablative, Moxi offers greater versatility and depth options, making it suitable for a wider range of skin concerns. Clear + Brilliant Permea is optimized for gentle, superficial treatments, providing a less aggressive approach to skin rejuvenation.