What should I keep in mind before incorporating any of these weight loss supplements into my routine?

I visited the site you mentioned, RawSci, and while they offer a variety of supplements—such as detox blends, energy-boosting formulas, collagen, vitamins, and herbal extracts—none appear specifically aimed at weight loss. Most of their offerings seem oriented toward general wellness or cosmetic concerns, rather than clinically-validated weight management agents.
Weight-loss supplements are often enticing, but they come with significant limitations and risks. The FDA does not regulate dietary supplements for safety or effectiveness in the same way as prescription drugs. Products can contain undeclared or adulterated ingredients, potentially harmful stimulants, or medications that raise blood pressure or cause other dangerous effects.
Medical guidelines and expert reviews consistently raise concerns. The NIH notes that studies supporting many weight-loss supplements are limited, of poor quality, or based on ingredients tested in isolation—not in the combinations found on the market. Herbs like green tea extract, conjugated linoleic acid, chromium, glucomannan, and others show insufficient or conflicting evidence of benefit—and sometimes carry side effects.
Reported harms include liver injury (for example, Hydroxycut—linked to liver failure and documented FDA warnings), increased risk of heart rhythm problems or blood pressure spikes, and interactions with medications
Authoritative bodies such as the American Medical Association emphasize that physicians cannot ethically recommend over-the-counter weight-loss supplements, because their safety and efficacy remain unproven.The Harvard School of Public Health and other researchers strongly caution against their use due to known dangers. Verywell Health reinforces that most supplements—from metabolism boosters to weight-loss gummies—lack meaningful evidence and may pose health threats
If you’re tempted by formulas labeled as “natural GLP-1 stimulators” or “berberine, nature’s Ozempic,” be especially wary. Medical professionals warn that these are not equivalents to prescription GLP-1 receptor agonists like semaglutide or tirzepatide, which have strong clinical evidence and FDA approval for weight management. Even those medications—used under medical supervision—require proper assessment of risks, monitoring, and follow-up.
Instead of supplements, a safer, more effective route begins with a comprehensive, individualized plan involving lifestyle interventions—nutrition, physical activity, sleep, stress management—guided by a qualified healthcare team (doctor, registered dietitian, exercise professional). If warranted, clinically studied prescription medications may be considered as part of a structured, long-term treatment plan.
Before adding any supplement—even one labeled as “organic” or “natural”—consider these key points: how well it’s studied, possible side effects (especially on the liver, kidneys, heart, or medication interactions), how it fits into your overall health and goals, and whether you have medical conditions (like hypertension, diabetes, or renal concerns) that could increase risk. And always discuss anything new with your healthcare provider.