Yes, Botox can sometimes help with mild “accordion lines,” particularly when those lines are caused or made worse by repetitive muscle movement. The lower face has several muscles that can contribute to these creases, so treatment needs to be individualized rather than simply injecting the DAO. Botulinum toxin has been studied and used for several lower-face concerns, including perioral wrinkles, marionette-type lines, and mentalis activity. The important distinction is whether your accordion lines are dynamic or static. If you mainly notice them when smiling, talking, or moving your mouth, a small amount of Botox may soften the muscle activity responsible and make the lines less pronounced. If the lines are visible even when your face is completely relaxed, Botox alone is less likely to eliminate them because there may also be a component of skin laxity, collagen loss, or volume changes. Since you have already tried filler and RF microneedling and did not like the results, a conservative neurotoxin approach could be reasonable, depending on exactly which muscles are creating the folds. However, I would be particularly cautious around the mouth. The muscles in this area are important for speaking, eating, smiling, and keeping the lips properly sealed. Too much toxin or injection in the wrong location can temporarily affect lip movement, smile symmetry, or oral competence. At 37, I would generally favor very subtle treatment rather than trying to completely freeze the lower face. The goal would be to reduce the repetitive muscle forces that are creating the creases while preserving your natural expressions. So, yes, lower-face Botox may improve mild accordion lines, especially if they are predominantly movement-related, but it is unlikely to completely erase established lines. The exact muscles responsible matter much more than simply treating the DAO, and lower-face injections should be performed conservatively because of the functional anatomy in this area.