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Why does Spironolactone cause irregular menstruation? Is it safe for family history of breast cancer?

shadmaryam
How does Spiro affect each sex hormones? I took 200 mg Spironolactone for hair loss/hirsutism for 10 years with very good success. I stopped the drug bc I read that it disrupts estrogen metabolism. The irony is that while on Spiro I had very few/light periods and no breast pain. Off of Spiro I have pretty bad breast and period pain. If breast pain/painful periods are associated with poor estrogen metabolism it seems that perhaps Spironolactone had some protective effects in my case?

Answers (2)

From board-certified doctors and trusted medical professionals
Jeff Donovan, MD, PhD profile photo
Dr. Jeff Donovan, MD, PhD
Answered on Dec 2, 2017
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William Rassman, MD (retired) profile photo
Dr. William Rassman, MD (retired)
Answered on Sep 28, 2018
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