The short answer is yes, that seizures have been reported after treatment with Botox. Both newly diagnosed and in those with history of epilepsy. As to how these seizures happened is not clear. The risk would be considered exceedingly small. Botox is a protein that cannot cross the blood brain barrier easily. But also keep in mind that epilepsy affects 1% of the population and Botox treatment for different conditions such as cosmetic, excessive sweating, headaches, etc. are very commonly done. Millions of such procedures have been done. The two may happen in the same person is a matter of time. As far as a seizure happening soon after Botox injection in someone with epilepsy, it would be difficult to prove if it happened as a reaction to botox or that it may have happened on its own. It seems prudent to be aware of the fact seizures have been reported after getting Botox in someone with epilepsy.