Does Minoxidil Cause Wrinkles?

While minoxidil may not be main contributor to wrinkles, it does affect collagen. In the article, “Minoxidil: mechanisms of action on hair growth,” published in the British Journal of Dermatology 2004, it reveals minoxidil decreases the expression of lysine hydroxylase in collagen production. Additionally, it also suppresses collagen synthesis by rat vibrissae dermal papilla cells, both in monolayer cultures and in cells grown in collagen gels. Essentially, minoxidil can cause a degradation of skin’s collagen, which is what would probably cause the accelerated aging. However, skin problems are not listed as any of the side effects on the packaging of Rogaine or Spectral DNC.

Minoxidil promotes blood flow to the area it is placed. Causing wrinkles is not a known symptom of using Minoxidil.

I have read no reports of minoxidil causing wrinkles. However, hair loss and wrinkles might happen at about the same time so someone might be able to do a study showing a relationship. It is not cause and effect.