Botox and fillers can be used at the same time. There are times that we will do things in a certain sequence. For example, Botox may be our first line treatment, then injectables to get the desired result. In our office, we often do peels and then Botox and injectables. If the patient gets the Botox or injectable first, we wait three weeks.Remember that patients should be off of things that can cause the blood to be, "thin", and cause bleeding or brusing. (i.e. aspirin, ibuprofen, ginko, etc;).It is important to communicate with your experienced injector and be on the "same page" as to the desired result. Please have reasonable expectations. Jeffrey J. Roth, M.D., F.A.C.S.Board Certified Plastic SurgeonLas Vegas Plastic Surgery